S.E.M.I.: Side Effects May Include... Cover

IGDB / 370528

S.E.M.I.: Side Effects May Include...

2026 Arcade Hack and slash/Beat 'em up Indie
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedo Show full summary

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

World design Nicht eindeutig GameplayCombat-focused GameplayPuzzles Game modeCo-op Game modeMultiplayer

Deep dive / Spielprofil

Everything about S.E.M.I.: Side Effects May Include...: story and gameplay

A structured look at the narrative, game feel, and traits that define this game.

Story & context

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

12 weitere Tags
Traitaction combat Traitaction platformer Traitaction roguelike Traitcrazy Traitescape game Traitfunny Traitlogic puzzle Traitonline coop Traitphysics Traitphysics puzzles Traitpuzzle platformer Traitragdoll physics

Game profile / Plain language

S.E.M.I.: Side Effects May Include...: release, platforms, and facts

Studio, play style, releases, and official sources — compactly prepared from external IGDB data.

01
Studios & ownership

Studio & publishing

Developer
Two Horn Unicorn
Publisher
Two Horn Unicorn
Franchise
Standalone
02
So spielt es sich

Spielprofil

Modi
Co-operative, Multiplayer, Single player
Perspective
Third person
Themes
Action, Comedy, Party
03
Wo & wann

Platform releases

  • PC (Microsoft Windows) Nov 20, 2025
  • PC (Microsoft Windows) Jan 23, 2026

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